Schizophrenia Risk Genes Converge into Shifting Co-Expression Networks Across Brain Development, Ageing and Brain Regions

Giulio Pergola,Madhur Parihar,Leonardo Sportelli,Rahul Bharadwaj,Eugenia Radulescu,Giuseppe Blasi, Qiang Chen, Joel Kleinman,Yanhong Wang,Srinidhi Rao Sripathy,Brady Maher,Alfonso Monaco,Joo Heon Shin,Richard Straub, Thomas Hyde,Alessandro Bertolino,Daniel Weinberger

BIOLOGICAL PSYCHIATRY（2022）

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Abstract

Schizophrenia is thought to be a neurodevelopmental brain disorder with genetic risk being associated with shifting clinical phenomena across the lifespan. We investigated the convergence of schizophrenia risk genes in brain co-expression networks in postmortem human prefrontal cortex (DLPFC), hippocampus, caudate nucleus and in dentate gyrus granule cells, parsed by specific age periods.

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Key words

Emotion Regulation,Estrogen/Progesterone,Midlife Women,MRS Brain Imaging,Functional Brain Imaging

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