Gelatin-Mediated Coprecipitation Synthesis Of Copper Sulfide Nanoparticles For Photothermal Ablation Of Cancer Cells

CuS nanomaterials were prepared through a gelatin-mediated co-precipitation method. The effects of gelatin amount, reaction temperature and time on the morphology, phase and photo absorption were investigated. The results show that the optimized gelatin amount is 0. 25 similar to 0. 5 g, and the increased temperature or time can enhance the size and crystalline of CuS nanomaterials. CuS nanoparticles prepared with 0. 5 g gelatin at 80 degrees C for 6 h have the strongest near-infrared (NIR) photoabsorption. The 0. 1 mL aqueous dispersion containing 0. 4 mg/mL CuS-gelatin which is continuously irradiated by the 1064 nm laser with a power density of 1. 0 W/cm(2), and the temperature rising reaches a maximum value of 30. 8 degrees C at 300 s, yielding a photothermal conversion efficiency of 35. 7%. In addition, compared with bare CuS nanoparticles, CuS-gelatin exhibits the lower cytotoxicity. Importantly, cancer cells in vitro can be efficiently ablated by the photothermal effect of CuS-gelatin with the irradiation of 1064 nm laser for 10 min.