手性5,5'-双(二苯基磷)-4,4'-二-1,3-苯并二噁唑的合成工艺

Yun-fei LI,Duo ZHOU,Shun-wei ZHAO,Min-qing SUN,Yao ZHANG,Hui CHEN

Synthetic Materials Aging and Application（2020）

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Abstract

将4-溴-1,2-亚甲二氧基苯与金属镁反应得到格式试剂后再与二苯基次膦酰氯进行反应,合成亚甲二氧基苯基膦酰,碘代后经乌尔曼偶联形成双二苯基膦酰结构,经过手性拆分后得到5,5'-双(二苯基磷酰)-4,4'-二-1,3-苯并二噁唑,最后用三氯硅烷还原后得到对空气稳定手性配体的(R)-(+)-5,5'-双(二苯基磷)-4,4'-二-1,3-苯并二噁唑.其结构经过核磁进行了表征.

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