Construction Of Pda/Rgdc/Zinc Oxide Quantum Dot Composite Coatings With Antibacterial Activity And Biocompatibility On Surface Of Titanium Implants

Traditional antibiotics to treat bacterial infections often lead to bacterial resistance to antibiotics, leading to the formation of drug-resistant bacteria, which has a greater risk to human health. A novel surface system was designed to provide a reliable self-antimicrobial platform for titanium implants without the use of antibiotics. This feature was achieved by constructing the composite coating on PDA(polydopamine)/RGDC (arginine-glycine-aspartic acid-cysteine)/zinc oxide quantum dot (ZnO QDs) on titanium implant surface. The ZnO QDs obtained by particle growth method was modified by RGDC and connected to the PDA covering the surface on titanium implant. The composite coating was tested with different bacteria and mouse osteoblasts. The results show that it has an antibacterial rate against Escherichia coli up to 98.95% and has excellent biocompatibility. Hence, the surface coating will have a broad application prospect in the field of biomedical implant materials.