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Individualized Net Benefit estimation and meta-analysis using generalized pairwise comparisons in N-of-1 trials.

Joris Giai,Julien Péron,Matthieu Roustit,Jean-Luc Cracowski,Pascal Roy,Brice Ozenne,Marc Buyse,Delphine Maucort-Boulch

Statistics in medicine（2023）

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Abstract
GPC can be used to estimate individual Δ which can then be aggregated in a meta-analytic way in N-of-1 trials. GPC ability to easily incorporate patient preferences allow for more personalized treatment evaluation, while needing much less computing time than Bayesian modeling.
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Key words
N-of-1 trials,generalized pairwise comparisons,meta-analyzes,net benefit,personalized medicine
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