星点设计-效应面法优化三氧化二砷纳米粒制备工艺
Chemical Engineer(2018)
Abstract
研究As2O3聚氰基丙烯酸正丁酯纳米粒(As2O3-PBCA-NP)的制备工艺.采用乳化聚合法制备纳米粒,以Poloxamer 188、α-BCA和As2O3用量为考察因素,以包封率、载药量和平均粒径及归一值(OD)值为考察指标,采用星点设计-效应面法,对结果进行多元线性回归及二项式拟合,预测较佳工艺条件.结果显示,星点设计-效应面法得到的优化处方制备的样品包封率为87.61%,载药量为1.39%,平均粒径为195.6nm,形态为圆形,分散均匀.星点设计-效应面法优化As2O3-PBCA-NP的制备工艺可行简便.
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