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一种脲酶抑制剂NPPT的合成方法

Shandong Chemical Industry(2019)

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Abstract
本文以三氯硫磷和正丙胺为原料, 于反应釜中制得正丙基硫代磷酰二氯, 料液不经分离过滤, 直接采用"一锅法", 通入适量氨气反应制得正丙基硫代磷酰三胺 (NPPT), 目标产物纯度98.6%, 总收率80.5%.实验考察了缚酸剂种类、溶剂种类、原料配比对产品收率的影响.该工艺具有产品收率高, 生产成本低, 基本无三废排放, 操作简便省工, 易于实现工业化生产等优点.
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