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Donor Simvastatin Treatment Alters the Gene Expression Profile of Human Cardiac Allografts During Ischemia and Reperfusion: ISHLT 38th Annual Meeting and Scientific Sessions

Rainer Krebs,Matti Kankainen,E. Holmström,Jan Lukac,Teija Ojala,Pirkko Mattila,Antti I. Nykänen,Karl B. Lemström

Journal of Heart and Lung Transplantation（2018）

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Abstract
Recently, we were able to show in a randomized clinical trial that simvastatin treatment of brain-dead donors reduces ischemia-reperfusion injury in human cardiac allograft recipients. Here, we analyze myocardial transcriptome changes in cardiac allografts after donor simvastatin treatment.
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donor simvastatin treatment alters,human cardiac allografts,ischemia
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