基于COSMO-RS方法筛选低共熔溶剂及银杏叶类黄酮提取工艺优化
Science and Technology of Food Industry（2020）
Abstract
依据真实溶剂类导体屏蔽模型(Conductor-like Screening Model for Real Solvents,COSMO-RS),通过计算筛选出银杏叶中类黄酮提取所用的天然低共熔溶剂(Natural Deep Eutectic Solvents,NADESs).以类黄酮得率为考察指标,在单因素实验的基础上,采用Box-Behnken响应面法对提取工艺进行优化.结果 表明:氯化胆破/甘油体系(摩尔比1∶2)为较优的NADESs,当银杏叶与NADESs固液比为1∶30.7 (g/mL),73.2℃下提取4.1 h时,回归模型预测类黄酮理论得率可高达5.70％,与验证试验值5.68％基本一致.本研究采用计算机模拟与实验相结合方法,为天然产物提取所用溶剂的筛选及后续工艺优化提供参考.
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