蒲公英绿原酸固体分散体性能分析与比较
Food & Machinery(2017)
Abstract
利用固体分散技术增强绿原酸的体外溶出速率,将绿原酸固体分别与PVPK30和PEG4000按照料辅比(质量比) 1︰2,1︰4,1︰6,1︰8进行混合,比较4种料辅比所制备的固体分散体成品的体外溶解度、累积溶出度和稳定性,对最佳配料比采用电镜扫描分析.结果表明,以 PVPK30为载体,料辅质量比1︰4,制备绿原酸固体分散体,其溶解度、溶出度、稳定性都有所提高;扫描电镜(SEM)下显示固体分散体中绿原酸以非晶体形式存在于PVPK30中,表面许多小孔有利于药物的溶出与吸收.绿原酸-PVPK30固体分散体明显提高了绿原酸的体外溶解度和溶出度,明显优于原料药性能.
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