高效液相色谱-串联质谱法同时测定酒中6种对羟基苯甲酸酯类防腐剂
Food Research and Development(2019)
Abstract
建立高效液相色谱-串联质谱法(high performance liquid chromatography-tandem mass spectrometry,HPLC-MS/MS)同时测定酒中6种对羟基苯甲酸酯类防腐剂的分析方法.试样用乙酸乙酯提取,经Poroshell 120 EC-C18色谱柱(2.1 mm×75 mm,2.7μm)进行分离,在电喷雾电离(electrospray ionization source,ESI)源负离子模式下,进行多反应监测(multiple reaction monitoring,MRM).6种对羟基苯甲酸酯在5 ng/mL~2000 ng/mL的浓度范围内线性关系良好,相关系数r2>0.999,在低、中、高3个加标浓度水平下的平均回收率为79.1%~107.5%,相对标准偏差(relative standard deviation,RSD)为1.1%~9.1%(n=7).方法检出限(limit of detection,LOD)为0.8μg/kg~1.0μg/kg,定量限(limits of quantitation,LOQ)为3.1μg/kg~3.6μg/kg.
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