Eotaxin基因多态性与支气管哮喘的相关性研究
Practical Journal of Medicine & Pharmacy（2012）
Abstract
目的 探讨Eotaxin基因多态性与哮喘的相关性.方法 用单链构象多态性-四引物聚合酶链反应-限制性酶切方法对96例汉族哮喘儿童及96名汉族健康儿童Eotaxin-3+2497T/G单核苷酸多态性检测,并对此位点单核苷酸多态性与哮喘的易感性、血浆总IgE(TIgE)水平、嗜酸性粒细胞(eosinophil,EOS)计数相关性进行分析.结果 Eotaxin-3+2497位点哮喘组与对照组G等位基因的频率、哮喘组IgE浓度及EOS计数均有统计学差异(P值分别＜0.01、＜0.01和＜0.05).结论 Eotaxin-3 +2497T/G多态性与哮喘易感性、EOS数量及IgE水平相关.
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