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miR-1271-5p促进大鼠心肌细胞增殖

Zhi-wei CHEN,Lin-lin GUO,Jia-mei WU,Song TENG,Xiao-fang HU, Wei QUAN, De-hua WU, Yu-tong SUN, Chong ZHANG, Xiao-qing MING, Lin YANG,Wen-jing DOU,Yue ZHANG

Progress of Anatomical Sciences（2018）

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Abstract
目的 研究miR-1271-5p对大鼠心肌细胞增殖和凋亡的作用,以及对肌浆网钙ATP酶(SERCA2a)表达的影响,为临床上心衰药物研发提供临床前期数据. 方法 转染miR-1271-5p mimics(模拟物)至大鼠心肌细胞,MTS法检测心肌增殖情况;用实时荧光定量PCR方法检测miR-1271-5p对心肌细胞SERCA2a表达的影响. 结果 miR-1271-5p转染组心肌细胞活力明显高于对照miRNA转染组(P＜0.05),但SERCA2a表达水平没有显著差异. 结论 miR-1271-5p促进心肌细胞增殖,对临床心衰治疗有应用前景.
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