乙肝后肝硬化证候特点的蛋白质组学研究

Chinese Journal of Basic Medicine in Traditional Chinese Medicine(2013)

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Abstract
目的:探讨血清蛋白质组学对肝硬化中医病机研究的价值.方法:结合纳米金属螯合磁珠纯化技术和基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)技术,检测103例肝硬化患者、29例健康人群及29例慢乙肝患者的血清标本,探讨肝硬化的病程进展过程中及典型肝硬化中医证候群血清蛋白质组的差异.结果:建立慢乙肝和肝硬化各中医证候血清蛋白质诊断模型.结论:血清蛋白质组学有助于中医证候的研究.
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