Molecular characterization of high-grade serous ovarian cancers occurring in younger and older women

Olga T Filippova,Pier Selenica,Fresia Pareja,Mahsa Vahdatinia,Yingjie Zhu,Xin Pei,Nadeem Riaz,Kara Long Roche,Dennis S Chi,Nadeem R Abu-Rustum,Lora H Ellenson,Jorge S Reis-Filho,Dmitriy Zamarin,Britta Weigelt

Gynecologic Oncology（2021）

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摘要

•Germline BRCA1/2 mutations are less common in older women with HGSOC.•Genomic HRD features are more frequent in HGSOCs in younger women.•HGSOCs in older women more frequently harbor CCNE1 amplification.•HGSOCs have a dominant HRD signature in younger and aging signature in older women.

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关键词

Ovarian cancer,Extreme of ages,Molecular profiles,BRCA1/2,Homologous recombination DNA repair deficiency,PARP inhibitor

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