Monofluorinated 5-Membered Rings Via Fluoromethylene Transfer: Synthesis Of Monofluorinated Isoxazoline N-Oxides
ORGANIC & BIOMOLECULAR CHEMISTRY(2021)
摘要
The synthesis of five-membered rings using fluoromethylene transfer chemistry is an attractive method for building fluorinated products of high value. This work demonstrates for the first time that one-fluorine-one-carbon modification of a substrate could be a viable strategy to access monofluorinated five-membered rings. The synthetic methodology was developed to access monofluorinated isoxazoline-N-oxides in one step starting from substituted 2-nitroacrylates using fluoromethylsulfonium reagents.
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关键词
monofluorinated isoxazoline,fluoromethylene transfer,synthesis
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