Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib.

Cheryl A C Peretz,Lisa H F McGary,Tanya Kumar, Hunter Jackson,Jose Jacob,Robert Durruthy-Durruthy,Mark J Levis,Alexander Perl,Benjamin J Huang, Catherine C Smith

Blood advances（2021）

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摘要

Single-cell sequencing exposes previously unmeasurable complexity of tumor heterogeneity and clonal evolution on quizartinib. Single-cell sequencing reveals on- and off-target mechanisms of resistance to quizartinib, which can preexist therapy.

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