Ventricular features as reliable differentiators between bvFTD and other dementias

•Our results showed a consistent pattern of ventricle enlargement in the bvFTD patients, particularly in the anterior parts of the frontal and temporal horns of the lateral ventricles.•The estimation of the proposed ventricular anteroposterior ratio (APR) resulted in statistically significant difference compared to all other groups.•Our study proposes an easy to obtain and generalizable ventricle-based feature (APR) from T1-weighted structural MRI (routinely acquired and available in the clinic) that can be used not only to differentiate bvFTD from normal subjects, but also from other FTD variants (SV and PNFA), MCI, and AD patients.•We have made our ventricle feature estimation and bvFTD diagnosis tool (VentRa) publicly available, allowing application of our model in other studies.•If validated in a prospective study, VentRa has the potential to aid bvFTD diagnosis, particularly in settings where access to specialized FTD care is limited.