Harnessing Preclinical Data As a Predictive Tool for Human Brain Tissue Targeting
ACS chemical neuroscience（2021）
关键词
Blood-brain barrier (BBB),brain availability,passive permeability,Madin-Darby canine kidney (MDCK),P-glycoprotein (P-gp),multidrug resistance protein 1 (MDR1),breast cancer resistant protein (BCRP),central nervous system (CNS),efflux ratio (ER),National Institutes of Health (NIH),Netherlands Cancer Institute (NKI),cerebrospinal fluid (CSF),in vitro assays,transporters,in vitro to in vivo correlation (IVIVC),drug concentration,unbound fraction,human CNS exposure
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