N-terminal domain regulates steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors

Yoshinao Katsu,Islam M D Shariful,Xiaozhi Lin,Wataru Takagi,Hiroshi Urushitani,Satomi Kohno,Susumu Hyodo,Michael E Baker

The Journal of Steroid Biochemistry and Molecular Biology（2021）

引用 8|浏览6

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摘要

•GR N-terminal domain activates elephant shark GR.•GR N-terminal domain activates elephant shark MR.•GR DNA-binding domain activates elephant shark GR.

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关键词

Glucocorticoid receptor,Allosteric,Elephant shark,Steroid receptor evolution,Nuclear receptors

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