Brain activation changes following motor training in children with unilateral cerebral palsy: An fMRI study

•We observed brain activity changes in a fronto-parietal network in children with Hand-arm bimanual intensive therapy including lower extremities (HABIT-ILE).•The fronto-parietal network is related to motor skill learning.•We observed brain activity changes in the sensorimotor cortex with HABIT-ILE.•Sensorimotor changes were related to changes in everyday activity assessments.•Two brain activity patterns may indicate different functional recovery phases.