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NEW PI3K KINASE INHIBITOR

Liu Qingsong,Liu Jing,Zhang Xin,Liang Xiaofei,Liu Xiaochuan,Liu Juanjuan,Chen Cheng,Zhao Zheng,Wang Aoli,Wang Wenchao,Wu Hong,Wang Beilei,Wang Li

user-5f8411ab4c775e9685ff56d3（2016）

Cited 3|Views12
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Abstract
The present invention relates to a PI3K kinase inhibitor, comprising a compound of a formula I or pharmaceutically acceptable salts, solvate, ester, acid, metabolite, or a prodrug thereof, Y, W, Z, R1, R2, R3, and R4 being defined in the specification. The present invention further relates to a pharmaceutical composition of the compound of the formula I and a usage of the pharmaceutical composition in preparing drugs used to treat diseases mediated by PI3K kinase activation.
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Key words
Prodrug,Metabolite,Kinase,Stereochemistry,PI3K/AKT/mTOR pathway,Chemistry
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