Lineage-associated connexin 43 expression in bisphosphonate-exposed rat bones

Raimund H M Preidl,Kerstin Amann,Manuel Weber, Martin Schiller, Manuela Ringler,Jutta Ries,Friedrich W Neukam,Marco Kesting,Carol-Immanuel Geppert,Falk Wehrhan

Journal of Cranio-Maxillofacial Surgery（2021）

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摘要

Expression of signaling proteins in bone cells depends on their embryological mesoderm-derived (e.g. tibia) or cranial neural crest (CNC)-derived (e.g. jaw) origin. Connexin 43 (Cx43) is a gap junction protein that plays an essential role in the mode of action of bisphosphonates (BP). This study aimed to investigate Cx43 expression and the influence of BP application on mesoderm- and CNC-derived bone.

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关键词

Medication-related osteonecrosis of the jaw (MRONJ),Bisphosphonate,Jawbone

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