Cooperative Ligand-Promoted P(III)-Directed Ruthenium-Catalyzed Remote Meta-C–H Alkylation of Tertiary Phosphines

Herein, we disclose a ruthenium-catalyzed meta-selective C–H activation of phosphines by using intrinsic P(III) as a directing group. 2,2,6,6-Tetramethylheptane-3,5-dione acts as the ligand and exhibits an excellent performance in boosting the meta-alkylation. The protocol allows an efficient and straightforward synthesis of meta-alkylated tertiary phosphines. Several meta-alkylated phosphines were evaluated for Pd-catalyzed Suzuki coupling and found to be superior to commercially available ortho-substituted phosphines. The practicability of this methodology is further demonstrated by the synthesis of difunctionalized phosphines.