Bcl11a siRNA-585 for inhibiting B-cell lymphoma/leukemia 11A (BCL11A) expression and tumorous B cell proliferation and application thereof

The invention discloses Bcl11a siRNA-585 for inhibiting B-cell lymphoma/leukemia 11A (BCL11A) expression and tumorous B cell proliferation. The sequence of the sense strand of the Bcl11a siRNA-585 is 5'-GAAUCUACUUAGAAAGCGATT-3'; and the sequence of the antisense strand of the Bcl11a siRNA-585 is 5'-UCGCUUUCUAAGUAGAUUCTT-3'. The Bcl11a siRNA-585 can efficiently inhibit BCL11A expression, effectively inhibit tumorous B cell proliferation and promote tumorous B cell apoptosis. The invention also proves that the tumorous B cell proliferation is inhibited more effectively and the tumorous B cell apoptosis is promoted by combining the Bcl11a siRNA-585 and Bc1-2 siRNA. The Bcl11a siRNA-585 for inhibiting the BCL11A expression and the tumorous B cell proliferation has significance for developing new anti-B cell tumor gene medicaments and improving the treatment effect of B cell tumors.