Predictors of myocardial recovery in arrhythmia-induced cardiomyopathy: A multicenter study

Background Arrhythmia-induced cardiomyopathy (AIC) is characterized by improvement in left ventricular ejection fraction (LVEF) following arrhythmia treatment. Predictors of recovery in LVEF are not well understood. Objective We evaluated predictors of AIC recovery in a large multicenter cohort. Methods In total, 243 patients (age 65 +/- 11, 73% male) with AIC caused by atrial fibrillation (49%), atrial tachycardia (20%), and premature ventricular contractions (PVCs; 31%) were treated and included. LVEF was assessed before and after treatment. Patients were stratified by arrhythmia duration (known [KN, n = 132] vs. unknown [UKN, n = 111]), arrhythmia type, LVEF, and presence of structural heart disease (SHD). Results Arrhythmia treatment was rhythm control in 95%. Median arrhythmia duration in the KN group was 47 months (25-75th percentile, 24-80 months). Post treatment LVEF was higher in KN group (55.9 +/- 7 vs. 46.2 +/- 12%; p < .0001) but the degree of LVEF improvement was similar (21.2 +/- 9 vs. 19.4 +/- 11; p = .16). Comparing highest quartile (longest arrhythmia duration) versus the rest of the KN group, the extent of LVEF improvement was similar (21.5 +/- 8 vs. 21 +/- 9%; p = .1). Patients in lowest index LVEF quartile (n = 74) had more PVC-induced AIC, greater EF improvement after treatment (24 +/- 17 vs. 19 +/- 7%; p < .0001) but lower post treatment EF (45 +/- 14 vs. 54 +/- 8%; p < .0001) versus other patients. Patients with SHD had lower index EF (28 +/- 8 vs. 34 +/- 8%; p < .0001) and lower final EF (47 +/- 12 vs. 56 +/- 7; p MUCH LESS-THAN .0001). In multivariate regression, low index LVEF predicted myocardial recovery (odds ratio, 11.4; p < .005). Conclusions In this AIC cohort, LVEF improved regardless of arrhythmia duration or type but those with PVCs had lower index LVEF and had less recovery. Low index LVEF predicted LVEF recovery following arrhythmia treatment.