The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients With Treatment-refractory Infections
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY(2022)
Abstract
While advancements in cellular therapy have improved outcomes for patients with refractory leukemia, severe infections may hinder access. Granulocyte transfusions, in combination with anti-microbial therapy, may be a safe option to facilitate candidacy for chimeric antigen receptor T-cell therapy in patients with leukemia and prolonged immune-compromised status.
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Key words
granulocyte transfusions, chimeric antigen receptor T-cell therapy, acute lymphoblastic leukemia
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