Treatment Of Infantile Fibrosarcoma Associated To An Abdominal Aortic Aneurysm With Larotrectinib: A Case Report
PEDIATRIC HEMATOLOGY AND ONCOLOGY(2021)
Abstract
Infantile fibrosarcoma (IFS) is a rare pediatric tumor which often presents the ETV6-NTRK3 gene fusion. NTRK3 encodes the neurotrophin-3 growth factor receptor tyrosine kinase, a druggable therapeutic target. Selective tropomyosin receptor kinase (TRK) inhibitors, such as larotrectinib, have shown efficacy and safety in the treatment of IFS. We report a case of an abdominal IFS diagnosed in a newborn associated with an aortic aneurysm that was successfully treated with larotrectinib without relevant adverse effects.
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Key words
Abdominal aneurysm, infantile fibrosarcoma, larotrectinib, tropomyosin receptor kinase inhibitor
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