Synthesis, Anti-Ovarian Cancer Activity Evaluation And Docking Studies Of Pyran Derivatives

The synthesis and characterization of new pyran derivatives (1-3) were realized by means of infrared spectroscopy (IR), H-1 nuclearmagnetic resonance spectroscopy (H-1 NMR), high resolution mass spectrum (HRMS) and single crystal X-ray crystallography. The anti-proliferation activity of compounds 1-3 was investigated against human ovarian cancer cells CAOV3 by Cell Counting Kit-8 (CCK-8) assay. The RT-PCR assay was performed to detect the relative expression level of the Foxm1b in the CAOV3 cell line after treated with compounds 1-3. Furthermore, molecular docking studies supported the biological assay data and suggested that compared with compounds 1 and 3, compound 2 has stronger interaction with protein.