Lipid-Soluble Polyphenols From Sweet Potato Exert Antitumor Activity And Enhance Chemosensitivity In Breast Cancer
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION(2021)
摘要
Polyphenols are abundant in vegetables and fruit. They have been shown to have various anti-tumor, antioxidant, and antiinflammatory effects. Here, we extracted the lipid-soluble fraction of polyphenols from fermented sweet potato (Ipomoea batatas). These lipid-soluble polyphenols mainly contained caffeic acid derivatives with strong antioxidant ability, which we hypothesized to affect diseases for which oxidative stress is a factor, such as cancer. We therefore investigated the antitumor and chemosensitizing effects of lipid-soluble polyphenols on E0771 murine breast cancer cells. The lipid-soluble polyphenols accumulated in the cells' cytoplasm due to its high lipophilicity, and reduced reactive oxygen species through its strong antioxidant activity. The lipid-soluble polyphenols also arrested the cell cycle at G(0)/G(1) by suppressing Akt activity, and enhanced the cytotoxicity of anticancer agents. In this model, lipid-soluble polyphenols inhibited tumor growth and enhanced the efficacy of chemotherapy drugs. These results suggest the potential of lipid-soluble polyphenols as a functional food to support cancer therapy.
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关键词
polyphenol, breast cancer, functional food, chemotherapy, antioxidant
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