Laser Synthesis: A Solvent-Free Approach For The Preparation Of Phenylthiazolo[5,4-B]Pyridine Derivatives

We describe here a rapid and straightforward solvent-free method to access phenylthiazolo[5,4-b]pyridines using a Nd-YAG laser NANO-NY81-10 (lambda = 355 nm, 10 Hz pulse frequency; 8 ns pulse duration). This newly presented method successfully brings several improvements to the laser assisted synthesis of N,S-heterocycles. We are able to provide a solvent-, metal- and base-free method with good yield and a substantial reduction in reaction time.