PRE- AND POST-PARTURITION INSULIN RESISTANCE IN GHEZEL EWES (Ovis aries)
The Philippine Journal of Veterinary Medicine(2020)
Abstract
While there are several studies on insulin resistance in ruminants, information regarding this phenomenon in Ghezel ewes as a fat-tailed breed is rare. In the present study, the intra-venous glucose tolerance test was performed to evaluate insulin resistance in sheep. Five adult Ghezel ewes were selected at 4 weeks before parturition and followed at 2 weeks before, 2 and 4 weeks, and 2, 3, and 4 months after parturition. A blood sample was taken and dextrose 50% was administered at 500 mg/kg, 10 ml/ kg/hour. Blood samples were collected from all ewes prior to and 1, 2, 3, and 4 hours after dextrose infusion to analyze glucose and insulin levels. The glucose and insulin levels at Hour Four remained significantly higher than Hour Zero in pre parturition periods. Despite presence of high concentrations of insulin, high levels of glucose were seen in pre parturition periods which represented insulin resistance in these periods. Finally, the highest degree of insulin resistance was observed at pre parturition periods in Ghezel ewes and it may be concluded that protecting the ewes from insulin resistance at pre parturition periods may manage their metabolic healthiness.
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