Screening tests for endometrial cancer in the general population

Objectives This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To assess the diagnostic accuracy of potential screening tests for the detection of atypical hyperplasia (pre‐cancer) and endometrial cancer of all stages and grades in asymptomatic (healthy) women in the general population. Secondary objectives To determine the optimal endometrial thickness cut‐off value using transvaginal ultrasound scan for the screening of asymptomatic women for endometrial cancer and atypical hyperplasia. To investigate sources of heterogeneity in endometrial cancer screening studies, including: characteristics of the studied population including age, menopausal status (pre‐ and postmenopausal), country of study and risk status (body mass index (BMI) categories, diabetes mellitus, polycystic ovary syndrome (PCOS)); characteristics of index test such as cytological classification used and sampling device; methodological quality (low risk of bias compared to high risk of bias); disease factors (endometrioid versus non‐endometrioid, low grade versus high grade).