代谢应激和胰腺癌的发生发展
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition（2021）
Abstract
目前胰腺导管腺癌(PDAC)的有效临床治疗方案有限,5年生存率低于8％,因此迫切需要探索新的治疗策略.PDAC为了适应极端恶劣的微环境,在其演进过程中存在广泛的代谢重编程.代谢应激与癌基因激活(如KRAS)以及抑癌基因失活所触发的信号密切相关.同时,代谢异常重塑肿瘤微环境,协同促进PDAC的发展.本篇综述将重点阐述PDAC及其微环境中的代谢重编程,以探索PDAC治疗中潜在的靶标.
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Key words
Metabolism,Pancreatic ductal adenocarcinoma,Tumor microenvironment
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