Sulfonamides complexed with metals as mycobacterial biofilms inhibitors

Pauline Cordenonsi Bonez,Vanessa Albertina Agertt,Grazielle Guidolin Rossi,Fallon dos Santos Siqueira,Josiéli Demétrio Siqueira,Lenice Lorenço Marques,Gelson Noe Manzoni de Oliveira,Roberto Christ Vianna Santos,Marli Matiko Anraku de Campos

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases（2021）

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摘要

•Rapidly growing mycobacteria (RGM) causing infections by biofilm formation.•Semi-quantitative method of biofilm formation was adapted for macrotechnics.•Sulphonamides complexed with metals is a promising anti-adhesion agent.•Sulphonamides complexed with metal is a possible inhibitor of signaling of biofilm formation.

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关键词

Rapidly growing mycobacteria,Sulfonamides,Metals,Biofilm,c-di-GMP

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