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Micronization of Levofloxacin Using the RESS Method

E. N. Antonov,L. I. Krotova,G. V. Mishakov,V. K. Popov

Russian Journal of Physical Chemistry B（2021）

Cited 4|Views12
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Abstract
The antibacterial drug levofloxacin (LF) is micronized by the Rapid Expansion of the Supercritical Solution (RESS) method to obtain microparticles with a high level of bioavailability. Ethanol is used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF microparticles with the characteristic size of <10 microns are obtained.
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Keywords: superficial fluid technologies,RESS,micronization,antibacterial drugs,levofloxacin
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