Suppressing Nucleotide Exchange To Inhibit Kras-Mutant Tumors
CANCER DISCOVERY（2021）
摘要
Guanine nucleotide exchange factors (GEF) control the rate-limiting step of physiologic RAS activation. In this issue of Cancer Discovery, Hofmann and colleagues describe the discovery of a selective inhibitor targeting the GEF, SOS1, along with its preclinical effects in suppressing KRAS-mutant tumor growth.
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