Preparation and characterization of advanced resin based drug delivery system to improve therapeutic efficacy of huperzine A

Since last two decades, the controlled release systems have attracted more attention due to the several extraordinary features including better stability of the products and controlled drug release on followed by zero-order kinetics. Here, an advanced dental resin based controlled release system (DR-CRS) containing huperzine A (HupA) was developed to achieve a controlled drug release. The drug loaded tablet core was put into a polypropylene reservoir and then dental resin mixed with pore formers was coated on it as the controlled release layer. The effect of type and content of fillers, type and content of pore formers, and resin layer gain on the drug release was thoroughly investigated. The in-vitro drug release study showed that the optimized formulation had a total cumulative release of more than 95% in 8 h. The pharmacokinetic study revealed that the Cmax value of DR-CRS was lower than that of the commercial tablets, the Tmax value was prolonged, demonstrating the prominent controlled release performance of HupA. Furthermore, the DR-CRS with a relative bioavailability of 88.36% displayed good absorption. The advanced DR-CRS was capable of providing a satisfactory alternative to release the drug in a controlled manner, which would better meet the needs of the market and industrial production.