XBP1s repression regulates Kupffer cell polarization leading to immune suppressive effects protecting liver allograft in rats

Weikang Zhang,Ding Cao,Menghao Wang,Yakun Wu,Jianping Gong, Jingzheng Li,Yiming Liu

International Immunopharmacology（2021）

引用 8|浏览4

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摘要

•Acute rejection response is still the leading cause of liver graft loss and failure.•We uncovered an immune regulatory role of X-box binding protein 1 (XBP1) on the immune function of Kupffer cells (KCs) which influence the immune response after liver transplantation.•XBP1s protected rat’s liver allograft via JAK-STAT mediated KCs polarization.

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关键词

XBP1s,JAK1-STAT1,Kupffer cells,M1/M2,T cells,Liver transplantation

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