PRF1 is a prognostic marker and correlated with immune infiltration in head and neck squamous cell carcinoma

Fan Cui,Hu Haixia,Shen Yilin,Wang Quan,Mao Yufeng,Ye Bin,Xiang Mingliang

Translational Oncology（2021）

引用 13|浏览7

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摘要

•The cytotoxic protein PRF1 is essentially involved in anti-tumour immunity.•PRF1 is overexpressed in advanced HPV+ HNSCC and correlates with better OS.•PRF1 expression correlates with tumour infiltrating CD8+ t cells and dendritic cells in HPV+ HNSCC.•PRF1 expression correlates with gene markers of t cell exhaustion in HNSCC.

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关键词

PRF1,prognosis,head and neck squamous cell carcinoma,tumor immune infiltration,HPV

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