Characterization of degradation products of celiprolol hydrochloride using hyphenated mass and NMR techniques

•First report regarding investigation of degradation behaviour of Celiprolol hydrochloride under ICH prescribed stress testing conditions.•A total of seven degradation products identified in various forced degradation conditions.•Usage of mass (LC-HRMS and LC–MSn) and NMR (NMR and LC-NMR) tools for the characterization of degradation products.•Mechanistic explanation for the formation of each degradation product.•In silico prediction of ADMET properties of Celiprolol hydrochloride and its degradation products.