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cAMP-PKA signaling is involved in regulation of spinal HCN channels function in diabetic neuropathic pain

Yanqiao Ma,Ji Chen,Deqian Yu,Bangcong Wei,Huan Jin,Junwei Zeng,Xiaohong Liu

Neuroscience Letters（2021）

Cited 13|Views1
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Abstract
•Diabetic neuropathic pain increases the expression of spinal HCN2, 4, PKA and the formation of cAMP.•Inhibition of cAMP and PKA reduces the expression of spinal HCN2 and HCN4 channels.•Blockade of HCN channels by ZD7288 decreases spinal cAMP levels and PKA protein expression.
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Diabetic neuropathic pain,HCN channels,cAMP,PKA
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