Preparation method of core-shell nanoparticles based on lipid membrane and metal organic framework

The invention relates to a preparation method and application of a drug carrier. The preparation method comprises preparation of ZIF-M nanoparticles, preparation of ZIF-M@PVP/DMPC nanoparticles and preparation of ZIF-M@LIP nanoparticles. According to the invention, the main materials of the nanoparticles are ZIF-8 and lipidosome, and are low in toxicity, good in biocompatibility and good in degradation capacity, so that the problem of toxic residues in a chemical synthesis method is solved; the prepared nanoparticles have the advantages of high crystallinity, uniform particles and stable physical and chemical properties; reaction raw materials are cheap and easy to obtain, the preparation method is simple in process and high in operability, and production and application requirements can be further met; and when IR780 is embedded into the lipid shell of the nanoparticle, controllable release of the drug, namely pH and near-infrared NIR controlled release of the drug, can be realized.