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Hyperforin alleviates the psychiatric disorders of adult rats suffered from early maternal separation via activating autophagy

Shengwen Wang,Shaofan Wang,Yi Wang,Yu Xin,Jinyue Zhang,Zhuo Yang,Chunhua Liu

Neuroscience Letters（2021）

Cited 7|Views11
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Abstract
•Hyperforin decreased the damage of autophagy in the hippocampus of early maternal separation rats.•Hyperforin reduced the excitotoxicity of the hippocampus of early maternal separation rats.•Hyperforin alleviated the impairment of autophagy by inhibiting the Notch1 receptor.
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Key words
Anxiety,Autophagy,Depression,Hyperforin,Notch1 receptor
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