Clonal evolution detected with conventional cytogenetic analysis is a potent prognostic factor in adult patients with relapsed Philadelphia chromosome-negative acute lymphoblastic leukemia

Hiroaki Shimizu,Akihiko Yokohama,Takuma Ishizaki,Nahoko Hatsumi,Satoru Takada,Takayuki Saitoh,Toru Sakura,Hiroshi Handa

Leukemia Research（2021）

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摘要

•Half of Ph-negative ALL patients acquired additional cytogenetic abnormalities (ACA).•Patients with ACA acquisition showed the significantly inferior survival rate.•Allogeneic transplant could not conquer this dismal subset of Ph-negative ALL.

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关键词

Acute lymphoblastic leukemia,Cytogenetic abnormality,Relapse,Clonal evolution,Allogeneic stem cell transplantation

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