A Novel Model of Acute Myocardial Ischemia in Human Ventricular Cardiomyocytes

Acute myocardial ischemia is known to be a pathology with a high mortality worldwide. In the last decades, computational simulation has been a widely used tool to study the electrophysiological effects of ischemia. In this work, we present an up-to-date model of the effects of myocardial ischemia in the action potential which includes more ischemia-affected current alterations than any other previously published model. The model was used to simulate action potentials during a 10-minute period of dynamic ischemia, and the main biomarkers of the action potential were monitored, as well as the extracellular potassium elevation. The results agree with those obtained experimentally, suggesting that the model can be useful for 3D simulations of acute myocardial ischemia.