SARS CoV2 infection _The longevity study perspectives

Domenico Lio,Letizia Scola,Rosa Maria Giarratana,Giuseppina Candore,Giuseppina Colonna-Romano,Calogero Caruso,Carmela Rita Balistreri

Ageing Research Reviews（2021）

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摘要

•The clinical outcome of SARS-CoV-2 infection is largely variable, and with differential age/gender related manifestations.•Some exceptional individuals recover from illness and COVID-19 complications in spite of their extreme age (nonagenarians/centenarians).•Studies on genetic and epigenetic factors on longevity trait might characterize the resistance to SARS-CoV-2 infection.•Long-lived Italian people, with multi-omics investigations could identify genetic/epigenetic basis of resistance and pharmacological targets for preventing or reducing viral infection in susceptible individuals.

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关键词

ACE,ACE/DD,ACE2,ADAM-17,Ang,aPTT,ARDS,AT1R,AT2R,BMI,CCR5Δ32,COVID-19,Cox 2,CpGIs,D,DBP,DCs,DIC,DUSP1,EC,EH,ET-1,FDP,FGF21,FluAV,HDACs,HIV-1,hPIV2,HSPs,I,IFN-γ,INR,IP-10,LPS,5-LO,MAPK,MKP-1,MCP1,MI,Mphi,NAD,NF-Kb,NK,NO,ORF,PAI-1,PC,PCR,PD,PT,PTMs,RANTES,RAS,RBD,RFLP,ROS,RSV,SARS CoV2,SARS-1,SBP,SIRT-1,SNP,SSCP,ssRNA,T2DM,TGF-β,Th1,TLR4,TNFR,TNF-α

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