A DNA nanosensor for monitoring ligand-induced i-motif formation
Organic & Biomolecular Chemistry(2021)
Abstract
Herein, we present a gold nanoparticle (GNP)-based DNA nanosensor to detect the formation of an i-motif from the random coil structure by small molecules at physiological pH. The nanosensor shows a distance dependent fluorescence turn-off response in the presence of a ligand, indicating conformational changes from the C-rich single stranded DNA into an i-motif.
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Key words
dna nanosensor,ligand-induced,i-motif
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