Challenges Estimating Patient Organs Doses Undergoing Enhanced Chest Ct Examination: Exploratory Study

Purpose: Estimate organs doses (ODs) of patients subjected to unenhanced (S1) and enhanced (S2) chest CT studies relying on image parameters such as Hounsfield Units (HUs). Materials and Methods: CT scans and images of a total of 16 patients who underwent two series of chest CT studies were obtained and retrospectively examined. OD increments of liver and pancreas for both series (S1 & S2) were estimated using two different independent methods, namely simulation approach using CT-EXPO and Amato's phantom-based fitting model (APFM). HUs were quantified for each organ by manually drawing fixed area-sized regions of interest (ROIs). The mean HUs were collected to obtain the ODs increments following APFM. Regression analysis was applied to find and assess the relationship between the HUs and the OD increments estimated using APFM and that using CT-EXPO. Spearman Coefficient and Wilcoxon Matched Paired t-test were conducted to show statistical correlation and difference between ODs increments using the two methods. Results: A strong significant difference was depicted between S1 and S2 scan series of liver and pancreas using CT-EXPO simulation. Mean HU values for S1 were lower than S2, resulting in statistically significant (p < 0.0001) HU changes. CT-EXPO simulation yielded significantly higher difference in ODs compared to the APFM for liver (p = 0.0455) and pancreas (p = 0.0031). Regression analysis revealed a strong relationship between HU of S1 and S2 and ODs increments using APFM in both organs (R-2 = 0.99), dissimilar to CT-EXPO (R-2 = 0.39 in liver and R-2 = 0.05 in pancreas). Conclusions: Although CT-EXPO allows for estimating ODs accounting for major acquisition scan parameters, it is not a reliable tool to evaluate the impact of contrast enhancement on ODs. On the other hand, the APFM accounts for contrast enhancement accumulation yet only provides relative OD increments, an information of limited clinical use.