LncRNA-WAS and Lncrna-C8807 Interact with Mir-142A-3p to Regulate the Inflammatory Response in Grass Carp
Fish & shellfish immunology(2021)
摘要
Septicemia of grass carp is a systemic inflammatory reaction caused by bacterial infection. More and more evidences show that long non-coding RNAs (lncRNAs) can participate in the regulation of inflammatory response. In the present study, lncRNA-WAS and lncRNA-C8807 were confirmed to be involved in the inflammatory response following infection with Aeromonas hydrophila. LncRNA-WAS and lncRNA-C8807 could interact with miR-142a-3p. LncRNA-WAS and lncRNA-C8807 interact with miR-142a-3p to effect pro-inflammatory genes and NF-κB pathway. Our results provide a theoretical basis for studying the molecular mechanism underlying the regulation of inflammation by lncRNA in grass carp.
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关键词
Ctenopharyngodon idella,lncRNA-WAS,lncRNA-C8807,miR-142a-3p,Aeromonas hydrophila,Innate immunity
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